Advances in Cancer Research, Vol. 61 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

Quantity sixty one of "Advances in melanoma study" comprises assurance of the subsequent: molecular techniques to melanoma treatment, radiation resistance, melanoma prevention learn trials, mammalian gene amplification, retinoblastoma gene functionality, molecular genetic foundation of breast melanoma, and tumour promoting through okadaic acid category compounds.

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83,496-500. De Cosse, J. ,and Lesser, M. L. ]. Natl. Cancer Inst. 81, 1290-1297. Deschner, E. , and Lynch, H. T. (1988). Cancer 61,2286-2290. , and Redmond, C. ]. Natl. Cancerlnst. 83, 1278-1280. , Shekelle, T. , Crique, M. , Rossof, A. , Paul, 0. (1985). Lancet 1, 307-309. , ef al. (1982). Lancet 2, 710-712. Greenwald, P. (1989). In “Principles and Practice of Oncology” (V. T. Devita, S. Hellman, and S. A. , p. 176. Lippincott, Philadelphia. , Nixon, D. , Malone, W. , Kelloff, G. , Stern, H. , and Witkin, K.

It is possible to extract DNA from paraffin embedded material, but this DNA is of low molecular weight, making Southern blot analysis unreliable. Most institutes receiving tumor material have only recently started to collect and store frozen tumor tissues; therefore the follow-up time for the patients in most studies is relatively short. Using hybridization of Southern blots with tumor DNA samples with a variety of oncogene probes, amplification of a number of genes has been found relatively frequently in breast cancer (Table 11).

MOLECULAR GENETICS IN BREAST CANCER 39 B. POINTMUTATIONS T h e only point mutations thus far detected in human cancer are those in the rm family of genes, in the p53 gene and in the prohibitin gene (for the latter two, see Section 11,D). Mutations in the rm genes are rare in human breast cancer. , 1988). , 1984). Two more breast cancer cell lines have been shown to contain ras gene mutations, affecting the c-Ki-rm gene in both cases. , 1989). From this it appears that rm gene mutations affect only a minor proportion of all tumors.

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