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Extra info for Advances in Immunology, Vol. 31
In my opinion, these studies have established that ( a )T cells will not grow in culture upon antigen stimulation in the absence of phagocytes; (b) phagocytes are required as an essential antigen-presenting cell; ( c ) the Z region regulates the interaction between the T cell and the macrophage; ( d )the phagocytes interacting with the T cell must express Ia antigens on their membranes; ( e )the Z-region involvement in macrophage interaction applies to all antigens, even those under no obvious Ir gene control; and cf)the interaction between the T cell and the appropriate macrophage selects and maintains the life of the antigen-Ia-reactive T-cell clone.
They found a major difference if the T cells were incubated with macrophage-bound antigen or with soluble antigen in the absence of macrophages. Normal spleen cells were cultured on ovalbumin bound to syngeneic peritoneal macrophages for 5 days, after which their function as helper cells was assayed by in vivo adoptive transfer; the T cells were inoculated with DNP-hemocyanin-primed B cells into X-irradiated mice, which were boosted with DNP-ovalbumin and then assayed for the IgG and IgE anti-DNP response.
Their results indicated an excellent generation of carrier-primed T cells by immunization with the macrophage-bound antigen. The experimental system was then manipulated using X-irradiated mice that received mixtures of thymus, bone marrow cells, and antigen-bearing macrophages. Excellent carrier-primed ceIls were found in spleens of X-irradiated mice injected simultaneously with thymocytes and macrophages, followed 8 days later with bone marrow cells; the reverse, however, giving bone marrow cells with macrophages first, followed 8 days later with the thymocytes, did not result in induction of carrierspecific T cells.