By Frederick W. Alt (ed.), K. Frank Austen (ed.), Tasuku Honjo (ed.), Fritz Melchers (ed.), Jonathan W. Uhr (ed.), Emil R. Unanue (ed.)
Advances in Immunology, a protracted verified and hugely revered ebook, provides present advancements in addition to accomplished stories in immunology. Articles deal with the wide variety of subject matters that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored via the key scientists within the box, every one quantity presents updated info and instructions for destiny examine.
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Extra resources for Advances in Immunology, Vol. 95
Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. Immunity 21, 443–453. Dejardin, E. (2006). The alternative NF-kappaB pathway from biochemistry to biology: Pitfalls and promises for future drug development. Biochem. Pharmacol. 72, 1161–1179. , and Singh, H. (2000). Regulation of B lymphocyte and macrophage development by graded expression of PU. 1. Science 288, 1439–1441. Dekoter, R. , Lee, H. , and Singh, H. (2002). 1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.
2000), indicating involvement of NF-kB signaling in developmental progression beyond this stage. Also, these cells showed reduced levels of Bcl-2 and enhanced apoptosis suggesting that the importance of NF-kB may relate to its ability to mediate survival signals to the developing B lymphocytes. In support of this interpretation, enforced expression of a bcl-2 transgene blocked the elevated apoptosis and promoted further differentiation of c-relÀ/ÀrelaÀ/À B lymphocytes. , 1993). , 1997). Since both developmental arrest and decreased survival of particular subsets would each manifest themselves as similar phenotypes, Fate Decisions During B Lymphopoiesis 33 it is at present unknown whether particular signaling pathways affect BCR-induced programs directing continued developmental progression or, alternatively, survival and turnover.
Nat. Immunol. 4, 38–43. , Riley, R. , and Blomberg, B. B. (2003). Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J. Immunol. 170, 719–726. Fruman, D. , Snapper, S. , Yballe, C. , Yu, J. , Alt, F. , and Cantley, L. C. (1999). Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 283, 393–397. , Turck, C. , and Chan, A. C. (1998). BLNK: A central linker protein in B cell activation.