By Zhifei Dai
This booklet highlights the hot advances in nanotheranostics from easy learn to strength purposes, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. every one bankruptcy demonstrates multifunctional nanoparticles with subject matters overlaying focusing on, imaging, supply, diagnostics, and treatment as new modalities for melanoma theranostics. This complete publication offers professional perspectives at the most up-to-date advancements in theranostic nanomedicine.
It specializes in capability theranostic purposes of multifunctional nanoparticles starting from picking out noninvasively melanoma cells by way of molecular detection, and visualizing in vivo drug supply via distinction stronger imaging, to destroying melanoma cellphone s with minimum negative effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally offers an interdisciplinary survey of nanotheranostics and as such is a precious source for researchers and scholars in similar fields.
Zhifei Dai is a Professor on the division of Biomedical Engineering, collage of Engineering, Peking college, China.
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Extra info for Advances in Nanotheranostics I: Design and Fabrication of Theranosic Nanoparticles
Fig. 13 Thermo-chemotherapy strategy to inhibition of breast cancer stem cells (CSCs) using polymer-modiﬁed and drug-loaded AuNRs. (a) A scheme to demonstrate that AuNRs serve as a combinatorial platform with thermo-chemotherapeutic capability of inhibiting cancer stem cells under laser irradiation. (b) UV-vis-NIR spectra of the pristine AuNRs and polyelectrolyte (PAA and PDDAC)-conjugated AuNRs. (c) Temperature curves of AuNRs after laser treatment. (d) Cell viability of human breast cancer cells (MCF-7) treated with Au@PAA@PDD, Au/SA@PDD, and SA (salinomycin) followed by NIR laser treatment, which triggers hyperthermia and SA release.
Copyright 2014, American Chemical Society) Additionally, HAuNSs can act as drug delivery system due to their hollow interior. Combined with the strong and tunable absorption band in the NIR region, HAuNSs are ideal theranostic platform for simultaneous cancer imaging and thermochemotherapy. Additionally, the size of HAuNSs (30–50 nm in diameter) is much smaller than AuNSs (>120 nm) and therefore exhibits increased extravasation from tumor blood vessels and higher intracellular uptake by mammalian cells.
F1) Scheme of SH-PEG-c(TNYL-RAW)-conjugated HAuNSs. (f2) Impact of NIR laser treatment on the growth of the bearing tumors in mice (Reprinted with permission from ref. . Copyright 2012, American Association for Cancer Research). (g) Polymer-coated AuNCs with capability of releasing chemotherapeutic drugs controllably under NIR light irradiation. (g1) Scheme of polymer-coated AuNCs for drug delivery. (g2) Effects of nanocarriers on cell viability after treatments: (C-1) 2 min irradiation in absence of AuNCs; (C-2) 2 min irradiation in the presence of Dox-free AuNCs; and (2/5 min) 2 min or 5 min irradiation by NIR laser in presence of Dox-loaded AuNCs (Reprinted with permission from ref.