Advances in Understanding Aortic Diseases by Geoffrey D. Rubin (auth.), Teruhisa Kazui M.D., Shinichi

By Geoffrey D. Rubin (auth.), Teruhisa Kazui M.D., Shinichi Takamoto M.D. (eds.)

Following the 1st foreign symposium ever held in Asia on Advances in figuring out Aortic illnesses (AUAD), this quantity of complaints includes the papers awarded in either the oral and poster periods. The eighth AUAD symposium vastly contributed to the knowledge of aortic illnesses, particularly in Asia. Aortic ailments, particularly thoracic aortic ailments, are extra universal in Japan than in Western nations, which provides extra significance to this compilation that covers contemporary advancements and advances in thoracic aortic surgical procedure and its results. Divided into lectures, panel discussions, symposiums, and poster periods, the publication comprises, between different issues, advances in imaging and analysis with 3D-CT, MRS, and US; cutting-edge fix of the thoracic aorta; novel features of aortic root substitute; reconstruction; and prosthetic graft surgical procedure. This precious choice of paintings offers the reader with an elevated wisdom and knowing of aortic ailments not just in Japan yet worldwide.

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Szekaneez Z, Shah MR, Pearce WH, et al (1994) Human atherosclerotic abdominal aortic aneurysms produce (IL)-6 and interferon-gamma but not IL-2 and IL-4: the possible role for IL-6 and interferon-gamma in vascular inflammation. Agents and Actions 42:159–162 39. Juvonen J, Surcel HM, Satta J, et al (1997) Elevated Circulating Levels of Inflammatory Cytokines in Patients with Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol 17:2843–2847 40. Longo GM, Xiong W, Greiner TC, et al (2002) Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms.

Newman KM, Ogata Y, Malon AM, et al (1994) Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arterioscler Thromb 4:1315–1320 46. Wilson WRW, Anderton M, Schwalbe EC, et al (2006) Matrix Metalloproteinase-8 and -9 Are Increased at the Site of Abdominal Aortic Aneurysm Rupture. Circulation 113:438–445 47. Allaire E, Forough R, Clowes M, et al (1998) Local over- expression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model.

Pharmacotherapy in AAA Management Pharmacotherapy aims to decrease the expansion and rupture rate of aortic aneurysms by modifying aortic wall biology. Having identified the need for pharmacotherapeutic treatment of a large cohort of patients currently managed by surveillance and risk factor modification [1], it is worth summarising the ideal properties such an agent requires for effective application. A common feature of the complexity of biologically evolved systems, that we have alluded to above, is redundancy of biological pathways [60].

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