Alkaloids: Chemistry and Pharmacology, Volume 14 by R.H.F Manske, H.L. Holmes

By R.H.F Manske, H.L. Holmes

Show description

Read or Download Alkaloids: Chemistry and Pharmacology, Volume 14 PDF

Similar chemistry books

Food Colorants: Chemical and Functional Properties (Chemical & Functional Properties of Food Components)

Drawing at the services of across the world recognized, interdisciplinary scientists and researchers, nutrition Colorants: Chemical and sensible homes offers an integrative snapshot of the medical features, performance, and functions of colour molecules as pigments in nutrients technology and expertise, in addition to their influence on well-being.

Wine: Flavour Chemistry

The economic significance of wine maintains to extend around the globe, with the provision of many new wines, encompassing a awesome and fascinating diversity of flavours. Wine Flavour Chemistry specializes in facets of wine making techniques which are very important within the improvement of flavour, describing many of the grapes used and their ensuing wines.

Additional resources for Alkaloids: Chemistry and Pharmacology, Volume 14

Sample text

The ketone 115 prepared from veralkamine was treated with ethaaedithiol. Desulfurization of the resultant thioketal 119 with Raney nickel yielded the (2-16 deoxo compound 120, which is identical with (22S,25S)-22,26-acetyl-epimino17P-methyl-18-nor-5a,13a-cholestan-3P01, also prepared from veralinine (118) via catalytic hydrogenation 28 J. TOMKO AND z. VOTICKY (121),acetylation (122),and partial saponification. The positions of the double bonds in veralinine were derived from the molecular rotation difference between 118 and 121.

Cyclovirobuxine-C (165) and cyclovirobuxeine-C (166) were obtained by a countercurrent distribution of the alkaloid mixture prepared by extracting the leaves of Buxus malayana (87). Cyclovirobuxine-C was not obtajn\:d pure because it crystallized with cyclovirobuxeine-C as shown in its PMR spectrum. To get a single product the mixture of 165 and 166 was hydrogenated over platinum catalyst and identified by spectral methods. The proposed structural formula of N-acetylated cyclovirobuxineC (167) was verified by comparison with the synthetically prepared product.

W. loauffrol)uxiiiiiie-~I trans-Cyclosuffrobuxinine-M Cyclovirobuxeine-C Cyclovirobuxine-D 218 312 260 262 166 181 386 367 353 353 414 402 205-210 Cyclovirobuxine-C Cycloxobuxidine-F ( = buxidine-F) 165 416 221 201 196 432 227-230 168 171 173 227 444 414 428 520 292 200-201 221-224 286-288 (dec) 291 252-255 235-238 (dec) 274-276 (dec) 277 214-216 (dec) 214-217 255-256 (dec) 292-294 278-279 Cyclomicrosine-C Cyclomicuranine-L C ycloprotobuxine-A Cvcloxobuxoxazine-C ( = haleabuxo'sazine-C) 16-lleoxvbuxidienine-C N-3-Benzoylcyclosobuxine-F - - 180 179 520 506 195 536 197 504 N-3-Benzoylcycloxobuxoline-F 200 520 N-3-Benzoyldihydrocyclomicrophylline-F ( = buxepidine) 193 522 201 156 230 226 562 442 504 486 ( = buxatine) N-3-Benzoyl-0-acetylcycloxobuxoline-P N-3-Isohutyrylcycloxobuxidine-F ( = N-isobutyrylbaleabuxidine-F) N-3-Isobutyrylcycloxobuxidine-H N-3-Mcthylbuxene-M 0-Tigloylcyclovirobnxeine-B 0-Vanilloylcyclovirobuxine-D Pseudobaleabuxine-F 170 502 232 264 158 191 488 441 496 552 470 - 235-236 235 141-142 228-230 282-284 209-211 206-207 205 195 163 167-172 181-182 - - 216-218 290 275 253 260-262 257 236-238 285 180-182 178-183 210 236-240 Sourcea Refs.

Download PDF sample

Rated 4.92 of 5 – based on 11 votes